Impact of Biannual Mass Azithromycin Treatment on Enteropathogen Carriage in Children <5 Years Old in Niger.

Platts-Mills, James A; Ayoub, Elias G; Zhang, Jixian; McQuade, Elizabeth T Rogawski; Arzika, Ahmed M; Maliki, Ramatou; Abdou, Amza; Keenan, Jeremy D et al. · Clin Infect Dis · 2022

rct · Level II

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Abstract

We analyzed samples obtained at baseline and 24 months in a mass azithromycin administration trial in Niger using quantitative polymerase chain reaction. In villages randomized to azithromycin, Shigella was the only pathogen reduced at 24 months (prevalence ratio, 0.36 [95% confidence interval: .17-.79]; difference in log quantity, -.42 [-.75 to -.10]).

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