Associations Between Autoimmune Conditions and Gastric Cancer Risk Among Elderly Adults in the United States.
case_control · Level III
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- Record sourced from PubMed, PMID 35029169.
- Also identified by DOI 10.14309/ajg.0000000000001622 and PMC identifier 8897246.
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Abstract
Pernicious anemia (PA) is a risk factor for gastric cancer. Other autoimmune conditions may also contribute. In a case-control study, we evaluated 47 autoimmune conditions among 39,125 gastric cancers and 200,000 cancer-free controls. Six conditions were associated with increased gastric cancer risk (range of adjusted odds ratios: 1.28-1.93, P < 0.05): PA, membranous nephropathy, primary biliary cirrhosis, pure red cell aplasia, primary sclerosing cholangitis, and Graves disease. PA was associated with 8 other autoimmune conditions (adjusted odds ratios: 1.57-4.54, P < 0.05). Autoimmune conditions associated with gastric cancer or PA may reflect effects of autoimmune gastritis or other carcinogenic pathways.
Medical subject headings
- Anemia, Pernicious
- Autoimmune Diseases
- Stomach Neoplasms