Collective dynamics of gastric cancer cells in fluid.

Abstract

Gastric cancer (GC) is the most common digestive system malignant cancer, and gastric cancer cells (GCC) can migrate in normal solid tissue and lymphatic fluid. Previously, much research has focused on the migration process when the cells are in the solid condition, such as migration through tissue, adhesion, and invasion processes, while little is known about the migration process of GCC in lymphatic fluid. In the current study, we investigate the migration of GCC in a fluid condition in an in vitro environment. We find that the cells diffuse mainly because of their cell viability. Therefore, despite the fact that lymph fluid is almost quiescent, GCCs can migrate around easily. The dynamics of cells also demonstrate a collective glassy dynamic similar to ordinary inactive glassy materials. As density of the cells increases, the movement of the cells becomes slower, and the collective dynamic becomes heterogeneous, which is similar to the dynamically heterogeneous behavior in glassy materials. The results will help us gain a better knowledge of the characteristics of GCC dynamics in the liquid phase which is crucial for the understanding of the mechanism for lymphatic metastasis. This can also potentially help early diagnosis of lymph node metastasis in GC and provide new insights for future clinical treatment.