Impact of cationic surfactant-induced DNA compaction on the characteristics of a minor groove bound flavonol.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35045144.
- Also identified by DOI 10.1039/d1sm01792f.
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Abstract
3-Hydroxyflavone (3-HF), which binds to the minor groove of DNA, is a strong antioxidant and hence a potent therapeutic and diagnostic agent. A special photo-property, called excited state intramolecular proton transfer (ESIPT), makes the 3-HF derivatives sensitive to the cellular hydrophobic microenvironment. The present study depicts the various changes in the ESIPT of 3-HF due to cationic surfactant-induced compaction of DNA.
Medical subject headings
- Protons
- Surface-Active Agents