Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35045587.
- Also identified by DOI 10.1002/adma.202108194 and PMC identifier 9028217.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays.
Medical subject headings
- Lasers
- Light