Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 35049467.
- Also identified by DOI 10.1192/bjp.2021.49 and PMC identifier 7612272.
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Abstract
Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic 'disinhibition' phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders.