The loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35063069.
- Also identified by DOI 10.1016/j.cell.2021.12.038 and PMC identifier 9195179.
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Abstract
The shock-and-kill strategy reactivates HIV-1 latent reservoir for immune clearance. Einkauf et al. found that some HIV-1-infected cells that persist and proliferate have transcriptionally active HIV-1 in permissive chromatin. Silent proviruses in repressive chromatin resist reactivation. Understanding HIV-1-chromatin interactions and how transcriptionally active HIV-1-infected cells survive is a pressing need.
Medical subject headings
- HIV Infections
- HIV-1