Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35065688.
- Also identified by DOI 10.1016/j.kint.2021.11.022.
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Abstract
Vascular calcification is a major manifestation of cardiovascular disease in advanced chronic kidney disease and is inhibited by vitamin K-dependent proteins. Clinical trials of vitamin K supplementation in chronic kidney disease have failed to demonstrate benefits on vascular calcification. Recent laboratory, human, and animal studies have shown that vitamin K handling and metabolism in chronic kidney disease is complex and suggest vitamin K2 subtype supplementation in isolation is unlikely to have significant clinical impact.
Medical subject headings
- Brassica
- Renal Insufficiency, Chronic
- Vascular Calcification