Dupuytren Cords Do Not Undergo Significant Histopathological Change After Collagenase Clostridium Histolyticum Injection.

Abstract

<b>Background:</b> Dupuytren disease creates thickened cords of the palmar fascia, leading to progressive flexion contractures that severely hinder hand function. Collagenase clostridium histolyticum (CCH) injection is a common, minimally invasive alternative to surgical excision of these cords. The impact of CCH injection on the histological architecture of Dupuytren cords has not been studied extensively. <b>Methods:</b> A series of 10 CCH-injected cords were evaluated histologically. Cellularity, architecture, and connective tissue organization were compared against uninjected Dupuytren cords and normal palmar fascia. <b>Results:</b> No significant histopathological differences between CCH-injected and CCH-uninjected cords were identified. <b>Conclusions:</b> Dupuytren cords do not demonstrate histological changes with prior exposure to CCH.