Generating 3D human cardiac constructs from pluripotent stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35093634.
- Also identified by DOI 10.1016/j.ebiom.2022.103813 and PMC identifier 8804169.
- Licence recorded as CC BY-NC-ND.
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Abstract
Human pluripotent stem cell (hPSC) technology has offered nearly infinite opportunities to model all kinds of human diseases in vitro. Cardiomyocytes derived from hPSCs have proved to be efficient tools for cardiac disease modeling, drug screening and pathological mechanism studies. In this review, we discuss the advantages and limitations of 2D hPSC-cardiomyocyte (hPSC-CM) system, and introduce the recent development of three-dimensional (3D) culture platforms derived from hPSCs. Although the development of bioengineering technologies has greatly improved 3D platform construction, there are certainly challenges and room for development for further in-depth research.
Medical subject headings
- Pluripotent Stem Cells