How β cells can smell insulin fragments.
Level V
Where this comes from
- Record sourced from PubMed, PMID 35108508.
- Also identified by DOI 10.1016/j.cmet.2022.01.003.
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Abstract
In this issue of Cell Metabolism, Cheng et al. identify olfactory receptor Olfr109 in β cells with increased expression in islets from mouse models of obesity and type 1 and type 2 diabetes. Binding of a small insulin fragment to Olfr109 fosters islet inflammation, β cell failure, and diabetes progression.
Medical subject headings
- Diabetes Mellitus, Type 2
- Insulin-Secreting Cells
- Islets of Langerhans