A microbiome-macrophage-iron axis guides stressed hematopoietic stem cell fate.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35120614.
- Also identified by DOI 10.1016/j.stem.2022.01.009.
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Abstract
The mammalian microbiota is a recently recognized regulator of hematopoiesis. In this issue of Cell Stem Cell, Zhang et al. (2022) show in mice that microbiota-derived butyrate enhances bone marrow macrophage erythrophagocytosis-dependent iron availability, which supports stress-induced hematopoietic stem cell differentiation and blood regeneration.
Medical subject headings
- Iron
- Microbiota