Quickly moving too slowly: Interneuron migration in Timothy Syndrome.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35120616.
- Also identified by DOI 10.1016/j.stem.2022.01.004.
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Abstract
Aberrant migration of GABAergic interneurons during cortical neurodevelopment is implicated in Timothy Syndrome, yet the underlying mechanisms remain elusive. In this issue of Cell Stem Cell, Birey et al. model developing brain circuitry using "assembloids" from patients, characterizing a bimodal mechanism of mechano-chemically driven interneuron migration inefficiencies.
Medical subject headings
- Autistic Disorder
- Long QT Syndrome
- Syndactyly