Genetic and non-genetic mechanisms of inflammation may promote transformation in leukemia.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35120617.
- Also identified by DOI 10.1016/j.stem.2022.01.006.
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Abstract
Non-genetic mechanisms of transformation are still relatively understudied and poorly understood. In this issue of Cell Stem Cell, Muto et al. provide preclinical evidence that loss of TRAF6 expression promotes transformation through a MYC-dependent mechanism that may be modulated by environmental inflammatory signals.
Medical subject headings
- Leukemia