Cell types of origin of the cell-free transcriptome.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35132263.
- Also identified by DOI 10.1038/s41587-021-01188-9 and PMC identifier 9200634.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cell-free RNA from liquid biopsies can be analyzed to determine disease tissue of origin. We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of cell types that contribute to cell-free RNA for a variety of diseases.
Medical subject headings
- Cell-Free Nucleic Acids
- Transcriptome