Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 35142337.
- Also identified by DOI 10.1093/cid/ciac115 and PMC identifier 9989354.
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Abstract
Genital inflammation (GI) undermines topical human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) efficacy through unknown mechanisms. Here, associations between activated endocervical CD4 + T-cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI.
Medical subject headings
- Anti-HIV Agents
- HIV Infections
- Pre-Exposure Prophylaxis