Cefiderocol for the Treatment of Infections Due to Metallo-B-lactamase-Producing Pathogens in the CREDIBLE-CR and APEKS-NP Phase 3 Randomized Studies.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 35148378.
- Also identified by DOI 10.1093/cid/ciac078 and PMC identifier 9522395.
- Licence recorded as CC BY-NC-ND.
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Abstract
In the CREDIBLE-CR and APEKS-NP studies, cefiderocol treatment was effective against gram-negative bacteria producing metallo-B-lactamases; rates of clinical cure (70.8% [17/24]), microbiological eradication (58.3% [14/24]), and day 28 all-cause mortality (12.5% [3/24]) compared favorably with comparators of best-available therapy and high-dose meropenem (40.0% [4/10], 30.0% [3/10], and 50.0% [5/10], respectively).
Medical subject headings
- Anti-Bacterial Agents
- Cephalosporins