Quantitative detection of hydrogen peroxide in rain, air, exhaled breath, and biological fluids by NMR spectroscopy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35165177.
- Also identified by DOI 10.1073/pnas.2121542119 and PMC identifier 8872725.
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Abstract
Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) plays a key role in environmental chemistry, biology, and medicine. H<sub>2</sub>O<sub>2</sub> concentrations typically are 6 to 10 orders of magnitude lower than that of water, making its quantitative detection challenging. We demonstrate that optimized NMR spectroscopy allows direct, interference-free, quantitative measurements of H<sub>2</sub>O<sub>2</sub> down to submicromolar levels in a wide range of fluids, ranging from exhaled breath and air condensate to rain, blood, urine, and saliva. NMR measurements confirm the previously reported spontaneous generation of H<sub>2</sub>O<sub>2</sub> in microdroplets that form when condensing water vapor on a hydrophobic surface, which can interfere with atmospheric H<sub>2</sub>O<sub>2</sub> measurements. Its antimicrobial activity and strong seasonal variation speculatively could be linked to the seasonality of respiratory viral diseases.
Medical subject headings
- Hydrogen Peroxide
- Magnetic Resonance Spectroscopy