Initiating Long-acting Injectable Naltrexone: Procedure for a Second Attempt After a First Attempt Fails.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 35165228.
- Also identified by DOI 10.1097/ADM.0000000000000974 and PMC identifier 9375774.
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Abstract
Many patients are unable to initiate long-acting injectable naltrexone (XR-NTX) on a first attempt, due to the prerequisite abstinence and withdrawal from opioids. Thirty patients who were unable to initiate XR-NTX were recruited to receive buprenorphine for 1 week, followed by a 3-week buprenorphine taper, and an ascending titration of oral naltrexone before XR-NTX injection. Eight (27%) initiated XR-NTX, 7 (23%) transitioned to buprenorphine maintenance treatment and 15 (50%) were lost to follow up. A second attempt at XR- NTX initiation using buprenorphine stabilization and cross taper may be a reasonable approach for some patients.
Medical subject headings
- Buprenorphine
- Opioid-Related Disorders