Arrested crossover precursor structures form stable homologous bonds in a Tetrahymena meiotic mutant.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35171923.
- Also identified by DOI 10.1371/journal.pone.0263691 and PMC identifier 8849441.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Meiotic DNA double-strand breaks produce reciprocally exchanged DNA strands, which mature into chiasmata that hold homologous chromosomes together as bivalents. These bivalents are subsequently separated in the first meiotic division. In a mutant lacking the newly identified Tetrahymena gene APRO1 (Anaphase promoting 1), meiosis is arrested by the end of prophase. Mature chiasmata are not formed but bivalents are connected via a molecular precursor structure. In-depth analysis of this arrested intermediate structure may help to elucidate the noncanonical molecular recombination pathway in Tetrahymena.
Medical subject headings
- Chromosomes
- DNA Breaks, Double-Stranded
- DNA Repair
- Homologous Recombination
- Meiosis
- Tetrahymena