Urodynamic effect of vibegron on neurogenic lower urinary tract dysfunction in individuals with spinal cord injury: A retrospective study.

Abstract

A Retrospective study. To investigate the effects of vibegron on urodynamic parameters of individuals with spinal cord injury (SCI). The National Hospital Organization, Murayama Medical Center, Japan. We retrospectively analyzed the urodynamic parameters of 31 individuals with SCI within one year after injury, who were diagnosed with neurogenic lower urinary tract dysfunction (NLUTD) according to a urodynamic study (UDS), and prescribed vibegron between December 2018 and December 2020. Treatment criteria were as follows: cystometric capacity of <200 mL, bladder compliance of <20 mL/cmH₂O, and/or presence of detrusor overactivity in the first UDS. We compared urodynamic data before and after vibegron treatment. Vibegron administration increased the maximum cystometric capacity (MCC) (median, from 185.0 to 340.0 mL, P = 0.001), bladder compliance (median, from 8.3 to 20.0 mL/cmH₂O, P < 0.001). Vibegron therapy improved the bladder capacity and bladder compliance of individuals with NLUTD and SCI.