Repetitive expanded T-cell receptor clonotypes impart the classic T helper 2 Sézary cell phenotype.
editorial · Level V
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- Record sourced from PubMed, PMID 35191024.
- Also identified by DOI 10.1111/bjd.21061.
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Abstract
Six out of 12 Sézary patients shared one clonotype (TRAV13-1*01-TRAJ49*01-TRBV20-1*01-TRBJ2-3*01). TRBV20-1*01 (also known as Vb2) that binds toxic shock syndrome toxin-1 was utilized by Sézary cells among half of the cohort, which would be expected for a common unifying origin.
Medical subject headings
- Sezary Syndrome
- Skin Neoplasms