The major genetic risk factor for severe COVID-19 is associated with protection against HIV.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35193979.
- Also identified by DOI 10.1073/pnas.2116435119 and PMC identifier 8892305.
- Licence recorded as CC BY-NC-ND.
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Abstract
There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative, <i>Nature</i> 600, 472-477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Pääbo, <i>Nature</i> 587, 610-612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an ∼27% lower risk of HIV infection.
Medical subject headings
- COVID-19
- Chromosomes, Human, Pair 3
- HIV Infections
- HIV-1
- Haplotypes
- SARS-CoV-2