CRISPR in cancer biology and therapy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35194172.
- Also identified by DOI 10.1038/s41568-022-00441-w.
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Abstract
Over the past decade, CRISPR has become as much a verb as it is an acronym, transforming biomedical research and providing entirely new approaches for dissecting all facets of cell biology. In cancer research, CRISPR and related tools have offered a window into previously intractable problems in our understanding of cancer genetics, the noncoding genome and tumour heterogeneity, and provided new insights into therapeutic vulnerabilities. Here, we review the progress made in the development of CRISPR systems as a tool to study cancer, and the emerging adaptation of these technologies to improve diagnosis and treatment.
Medical subject headings
- Clustered Regularly Interspaced Short Palindromic Repeats
- Neoplasms