Inflammation, Aging, and Cardiovascular Disease: JACC Review Topic of the Week.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35210039.
- Also identified by DOI 10.1016/j.jacc.2021.12.017 and PMC identifier 8881676.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Aging and inflammation both contribute pivotally to cardiovascular (CV) and cerebrovascular disease, the leading causes of death and disability worldwide. The concept of inflamm-aging recognizes that low-grade inflammatory pathways observed in the elderly contribute to CV risk. Understanding the mechanisms that link inflammation and aging could reveal new therapeutic targets and offer options to cope with the growing aging population worldwide. This review reports recent scientific advances in the pathways through which inflamm-aging mediates age-dependent decline in CV function and disease onset and considers critically the translational potential of such concepts into everyday clinical practice.
Medical subject headings
- Aging
- Cardiovascular Diseases
- Inflammation