An inhibitor of leukotriene-A<sub>4</sub> hydrolase from bat salivary glands facilitates virus infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35238649.
- Also identified by DOI 10.1073/pnas.2110647119 and PMC identifier 8915838.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
SignificanceAn immunosuppressant protein (MTX), which facilitates virus infection by inhibiting leukotriene A<sub>4</sub> hydrolase (LTA<sub>4</sub>H) to produce the lipid chemoattractant leukotriene B<sub>4</sub> (LTB<sub>4</sub>), was identified and characterized from the submandibular salivary glands of the bat <i>Myotis pilosus</i>. To the best of our knowledge, this is a report of an endogenous LTA<sub>4</sub>H inhibitor in animals. MTX was highly concentrated in the bat salivary glands, suggesting a mechanism for the generation of immunological privilege and immune tolerance and providing evidence of viral shedding through oral secretions. Moreover, given that the immunosuppressant MTX selectively inhibited the proinflammatory activity of LTA<sub>4</sub>H, without affecting its antiinflammatory activity, MTX might be a potential candidate for the development of antiinflammatory drugs by targeting the LTA<sub>4</sub>-LTA<sub>4</sub>H-LTB<sub>4</sub> inflammatory axis.
Medical subject headings
- Enzyme Inhibitors
- Epoxide Hydrolases
- Influenza A Virus, H1N1 Subtype
- Leukotriene A4
- Orthomyxoviridae Infections
- Salivary Glands
- Salivary Proteins and Peptides
- Virus Diseases