Human defensin-inspired discovery of peptidomimetic antibiotics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35238683.
- Also identified by DOI 10.1073/pnas.2117283119 and PMC identifier 8916014.
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Abstract
SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.
Medical subject headings
- Anti-Bacterial Agents
- Defensins
- Drug Discovery
- Peptidomimetics