Dual-function AzuCR RNA modulates carbon metabolism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35239434.
- Also identified by DOI 10.1073/pnas.2117930119 and PMC identifier 8915982.
- Licence recorded as CC BY-NC-ND.
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Abstract
SignificanceWhile most small, regulatory RNAs are thought to be "noncoding," a few have been found to also encode a small protein. Here we describe a 164-nucleotide RNA that encodes a 28-amino acid, amphipathic protein, which interacts with aerobic glycerol-3-phosphate dehydrogenase and increases dehydrogenase activity but also base pairs with two mRNAs to reduce expression. The coding and base-pairing sequences overlap, and the two regulatory functions compete.
Medical subject headings
- Carbon
- Escherichia coli
- RNA, Bacterial