Developmentally distinct CD4<sup>+</sup> T<sub>reg</sub> lineages shape the CD8<sup>+</sup> T cell response to acute <i>Listeria</i> infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35239442.
- Also identified by DOI 10.1073/pnas.2113329119 and PMC identifier 8915796.
- Licence recorded as CC BY-NC-ND.
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Abstract
SignificanceThe CD4<sup>+</sup> T<sub>reg</sub> response following acute <i>Listeria</i> infection is heterogeneous and deploys two distinct modes of suppression coinciding with initial pathogen exposure and resolution of infection. This bimodal suppression of CD8<sup>+</sup> T cells during priming and contraction is mediated by separate T<sub>reg</sub> lineages. These findings make a significant contribution to our understanding of the functional plasticity inherent within T<sub>reg</sub><sub>s</sub>, which allows these cells to serve as a sensitive and dynamic cellular rheostat for the immune system to prevent autoimmune pathology in the face of inflammation attendant to acute infection, enable expansion of the pathogen-specific response needed to control the infection, and reestablish immune homeostasis after the threat has been contained.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Listeria monocytogenes
- Listeriosis
- T-Lymphocytes, Regulatory