The RTS,S vaccine-a chance to regain the upper hand against malaria?

Sinnis, Photini; Fidock, David A · Cell · 2022

review · Level V

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Abstract

Malaria is estimated by the World Health Organization (WHO) to have killed 627,000 individuals worldwide in 2020, with nearly 80% of deaths in African children younger than five. The recent WHO approval of the RTS,S/AS01 vaccine, which targets Plasmodium falciparum pre-erythrocytic stages, provides hope that its use combined with other interventions can help reverse the current malaria resurgence.

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