Quo vadis, neutrophil?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35245478.
- Also identified by DOI 10.1016/j.cell.2022.02.009.
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Abstract
Neutrophil recruitment from blood into tissues is a hallmark of inflammation and anti-microbial host defense. In this issue, De Giovanni et al. describe an unanticipated role for a serotonin metabolite, 5-HIAA, which is produced by activated platelets and mast cells and engages the orphan receptor, GPR35, to recruit neutrophils to inflamed tissues.
Medical subject headings
- Blood Platelets
- Neutrophils