Real-World Incidence of Breakthrough Coronavirus Disease 2019 Hospitalization After Vaccination vs Natural Infection in a Large, Local, Empaneled Primary Care Population Using Time-to-Event Analysis.

Pollock, Benjamin D; Storlie, Curtis B; Tande, Aaron J; Sampathkumar, Priya · Clin Infect Dis · 2022

retrospective_cohort · Level III

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Abstract

We followed 106 349 primary care patients for 22 385 3099 person-days across 21 calendar months and documented 69 breakthrough coronavirus disease 2019 (COVID-19) hospitalizations: 65/102,613 (0.06%) among those fully vaccinated, 3/11 047 (0.03%) among those previously infected, and 1/7,313 (0.01%) among those with both statuses. These data give providers real-world context regarding breakthrough COVID-19 hospitalization risk.

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