HSP90 Mediates IFNγ-Induced Adaptive Resistance to Anti-PD-1 Immunotherapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35247909.
- Also identified by DOI 10.1158/0008-5472.CAN-21-3917.
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Abstract
This study reveals an HSP90-centric, iron-modulated mechanism that confers immunosuppression, offering potential therapeutic targets for interfering with acquired resistance to the most prevalent anticancer immunotherapies.
Medical subject headings
- HSP90 Heat-Shock Proteins
- Immunotherapy
- Interferon-gamma