Goal discrimination in hippocampal nonplace cells when place information is ambiguous.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35254897.
- Also identified by DOI 10.1073/pnas.2107337119 and PMC identifier 8931233.
- Licence recorded as CC BY-NC-ND.
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Abstract
SignificanceGoal-directed spatial navigation has been found to rely on hippocampal neurons that are spatially modulated. We show that "nonplace" cells without significant spatial modulation play a role in discriminating goals when environmental cues for goals are ambiguous. This nonplace cell activity is performance-dependent and is modulated by gamma oscillations. Finally, nonplace cell goal discrimination coding fails in a mouse model of Alzheimer's disease (AD). Together, these results show that nonplace cell firing can signal unique task-relevant information when spatial information is ambiguous; these signals depend on performance and are absent in a mouse model of AD.
Medical subject headings
- Discrimination Learning
- Hippocampus
- Spatial Navigation