Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35259022.
- Also identified by DOI 10.1073/pnas.2117013119 and PMC identifier 8931372.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.
Medical subject headings
- Acyl Coenzyme A
- NM23 Nucleoside Diphosphate Kinases
- Neoplasms