Standing Watch: Immune Activation and Failure in Melanoma Sentinel Lymph Nodes.
Where this comes from
- Record sourced from PubMed, PMID 35262676.
- Also identified by DOI 10.1158/1078-0432.CCR-22-0214 and PMC identifier 9106852.
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Abstract
An unbiased approach to map the sentinel lymph node landscape reveals progressive immune dysfunction associated with micrometastasis in patients with stage I-III cutaneous melanoma. Evidence of tumor-induced lymph node dysfunction may motivate new hypotheses for neoadjuvant therapy with potential to reinvigorate endogenous antitumor immunity. See related article by Yaddanapudi et al., p. 2069.
Medical subject headings
- Melanoma
- Sentinel Lymph Node
- Skin Neoplasms