CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35263032.
- Also identified by DOI 10.1111/acel.13589 and PMC identifier 9009115.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age-related NAD decline. Whether the inhibition of CD38 increases lifespan is not known. Here, we show that the CD38 inhibitor 78c increases lifespan and healthspan of naturally aged mice. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between sexes. Our study is the first to investigate the effect of CD38 inhibition in naturally aged animals.
Medical subject headings
- Longevity
- NAD