Differential T-Cell Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in mRNA-1273- and BNT162b2-Vaccinated Individuals.

Gallagher, Kathleen M E; Leick, Mark B; Larson, Rebecca C; Berger, Trisha R; Katsis, Katelin; Yam, Jennifer Y; Maus, Marcela V · Clin Infect Dis · 2022

cross_sectional · Level IV

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Abstract

COVID-19 breakthrough cases among vaccinated individuals demonstrate the value of measuring long-term immunity to SARS-CoV-2 and its variants. We demonstrate that anti-spike T-cell responses and IgG antibody levels are maintained but decrease over time and are lower in BNT162b2- versus mRNA-1273-vaccinated individuals. T-cell responses to the variants are relatively unaffected.

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