APOE Antibody Inhibits Aβ-Associated Tau Seeding and Spreading in a Mouse Model.
basic_science · Level V
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- Record sourced from PubMed, PMID 35285073.
- Also identified by DOI 10.1002/ana.26351 and PMC identifier 9285984.
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Abstract
APOE is the strongest genetic factor for late-onset Alzheimer's disease (AD). A specific conformation of the ApoE protein is present in amyloid-β (Aβ) containing plaques. Immunotherapy targeting ApoE in plaques reduces brain Aβ deposits in mice. Here, we evaluated the effects of the anti-human APOE antibody HAE-4 on amyloid plaques, Aβ-mediated tau seeding and spreading, and neuritic dystrophy in the 5XFAD amyloid mice expressing human ApoE4. HAE-4 reduced Aβ plaques as well as Aβ-driven tau seeding/spreading and neuritic dystrophy. These results demonstrate that HAE-4 may provide therapeutic effects on amyloid removal and Aβ driven downstream consequences such as tauopathy. ANN NEUROL 2022;91:847-852.
Medical subject headings
- Alzheimer Disease