Genetics, leadership position, and well-being: An investigation with a large-scale GWAS.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35286190.
- Also identified by DOI 10.1073/pnas.2114271119 and PMC identifier 8944770.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
SignificanceOur study presents the largest whole-genome investigation of leadership phenotypes to date. We identified genome-wide significant loci for leadership phenotypes, which are overlapped with top hits for bipolar disorder, schizophrenia, and intelligence. Our study demonstrated the polygenetic nature of leadership, the positive genetic correlations between leadership traits and a broad range of well-being indicators, and the unique association of leadership with well-being after accounting for genetic influences related to other socioeconomic status measures. Our findings offer insights into the biological underpinnings of leadership.
Medical subject headings
- Genome-Wide Association Study
- Schizophrenia