Correlation between structure and function in phosphatidylinositol lipid-dependent Kir2.2 gating.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35286194.
- Also identified by DOI 10.1073/pnas.2114046119 and PMC identifier 8944589.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
SignificancePhosphatidylinositol 4,5-bisphosphate (PI(4,5)P<sub>2</sub>) levels regulate cell membrane voltage by gluing two halves of a K<sup>+</sup> channel together and opening the pore. PI(4)P competes with this process. Because both of these lipids are relatively abundant in the plasma membrane and are directly interconvertible through the action of specific enzymes, they may function together to regulate channel activity.
Medical subject headings
- Phosphatidylinositol 4,5-Diphosphate
- Phosphatidylinositols
- Potassium Channels, Inwardly Rectifying