Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35294277.
- Also identified by DOI 10.1073/pnas.2111405119 and PMC identifier 8944747.
- Licence recorded as CC BY-NC-ND.
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Abstract
SignificanceOur results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson's disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy. The knowledge generated in this study could be used to devise novel therapeutic approaches to treat synucleinopathies.
Medical subject headings
- Induced Pluripotent Stem Cells
- Multiple System Atrophy
- Parkinson Disease
- Synucleinopathies