Donor-derived cell-free DNA in kidney transplantation: evolving concepts and potential limitations.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35314051.
- Also identified by DOI 10.1016/j.kint.2022.01.012.
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Abstract
Bu et al. report that elevated donor-derived cell-free DNA detected on serial measurements performed for both surveillance and assessment of kidney allograft dysfunction was associated with rejection, future de novo donor-specific antibodies, and decline in estimated glomerular filtration rate. Their data suggest that donor-derived cell-free DNA may be a useful indicator of kidney allograft health. In this commentary, we discuss the expanding role of donor-derived cell-free DNA for allograft surveillance and highlight potential limitations.
Medical subject headings
- Cell-Free Nucleic Acids
- Kidney Transplantation