Roll out the barrel! Outer membrane tension resolves an unexpected folding intermediate.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35325591.
- Also identified by DOI 10.1016/j.cell.2022.03.001.
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Abstract
How do bacteria assemble transmembrane β-barrels into their outer membrane in the absence of an energy source? New structures and experiments from Doyle et al. suggest that the β-barrel assembly machinery (BAM) co-opts the power of membrane elastic tension to help complete the folding of β-barrel outer membrane proteins.
Medical subject headings
- Bacterial Outer Membrane Proteins
- Escherichia coli Proteins