Probing RNA structures and functions by solvent accessibility: an overview from experimental and computational perspectives.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35348613.
- Also identified by DOI 10.1093/bib/bbac112 and PMC identifier 9116373.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Characterizing RNA structures and functions have mostly been focused on 2D, secondary and 3D, tertiary structures. Recent advances in experimental and computational techniques for probing or predicting RNA solvent accessibility make this 1D representation of tertiary structures an increasingly attractive feature to explore. Here, we provide a survey of these recent developments, which indicate the emergence of solvent accessibility as a simple 1D property, adding to secondary and tertiary structures for investigating complex structure-function relations of RNAs.
Medical subject headings
- RNA