Prolonged Cotrimoxazole Prophylaxis Has No Impact on Child Growth in the First Two Years of Life: Findings from a Randomized Controlled Trial in Botswana.

Mussa, Aamirah; Powis, Kathleen M; Lockman, Shahin; Ajibola, Gbolahan; Morroni, Chelsea; Smeaton, Laura; Mmalane, Mompati; Makhema, Joseph et al. · J Pediatr · 2022

rct · Level II

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Abstract

We investigated the impact of prolonged cotrimoxazole prophylaxis on growth in 2848 HIV-exposed uninfected children enrolled in the Mpepu study, a randomized, placebo-controlled trial in Botswana. No significant differences in mean weight-for-age, length-for-age, or weight-for-length z scores between placebo and cotrimoxazole arms were observed overall through 18 months.

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