Renal oxygenation measured by near-infrared spectroscopy in preterm neonates in the first week.

Abstract

To describe renal regional saturation of oxygen (RrSO₂) values during the first week of life for preterm neonates born at <32 weeks gestational age (GA). RrSO₂ values recorded over the first week of life using near-infrared spectroscopy were retrospectively analyzed in this two-center cohort study of preterm infants without known congenital anomalies of the kidney. A cohort of 109 neonates with a median GA of 26.9 weeks and a median of 120 (IQR: 87-141) hours of continuous RrSO₂ monitoring were included. Separately fitted trends in RrSO₂ did not differ (p = 0.52) between sites and demonstrated a consistent decrease in RrSO₂ by 20 points (95% CI: 9.6-30.1) during the first 60 h of life, followed by a stabilization of RrSO₂ thereafter. RrSO₂ baseline trends increased by 2.1 (95% CI: 0.8-3.3) percentage points for each additional week GA between 24 and 32 weeks GA. Despite differences in adjusted RrSO₂ values between sites, profiles over time are consistent, allowing for the determination of RrSO₂ trajectories in preterm infants. This expected pattern of RrSO₂ changes in the first week may help guide future investigations and interventions to identify and reduce kidney injury in the preterm neonate. Renal regional saturation of oxygen (RrSO₂) slowly decreases during the first 60 h of age in <32-week preterm neonates. While site differences were identified with respect to absolute values, RrSO₂ trends from two different centers were not different. Lower gestational age neonates have lower RrSO₂ levels during the first week.