Locally produced autoantibodies in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35364029.
- Also identified by DOI 10.1016/j.cell.2022.03.006.
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Abstract
The function and antigen-specificities of tumor-infiltrating B cells are mostly unknown. In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022).
Medical subject headings
- Autoantibodies
- Ovarian Neoplasms