CAR T cells are in it [CD]4 the long haul.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35364030.
- Also identified by DOI 10.1016/j.cell.2022.03.004.
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Abstract
In a recent issue of Nature, Melenhorst et al. perform an extensive analysis of CAR T cells that persist for ten years in CLL patients. They find a dominant cytotoxic CD4+ population, raising the possibility that CD4+ T cells play an important role in durable CAR T cell therapy.
Medical subject headings
- CD4-Positive T-Lymphocytes
- Immunotherapy, Adoptive
- Leukemia, Lymphocytic, Chronic, B-Cell