Biphasic Waning of Hemagglutination Inhibition Antibody Titers After Influenza Vaccination in Children.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 35380689.
- Also identified by DOI 10.1093/infdis/jiac117.
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Abstract
We explored the potential for a biphasic pattern in waning of antibody titers after influenza vaccination. We collected blood samples in a randomized controlled trial of influenza vaccination in children and tested them with hemagglutination inhibition assays for influenza A(H3N2) and influenza B/Victoria lineage. Using piecewise log-linear mixed-effects models, we found evidence for a faster initial waning of antibody titers for the first 1-2 years after vaccination and then slower longer-term declines. Children with higher postvaccination titers had faster antibody decay.
Medical subject headings
- Influenza Vaccines
- Influenza, Human